Our Facilities

The center has established three core units that are crucial for both basic and translational researches in gene and cell therapies. The viral vector cores are designed to compliment each other while provide streamlined support for bench to bedside projects. Our human stem cell core has established a number of protocols for both human ESC and iPSC lines. If you are interested in obtaining services from our core units via a service contract, please go to each core unit's page for detailed information.

Human Stem-Cell Vector Core

The hESC/iPSC core facility was established in 2008 within the Center for Cellular and Molecular Therapeutics at The Children’s Hospital of Philadelphia. The facility is located on the 5th floor of the new Colket Translational Research Building. Our mission is to provide expertise, quality-control reagents and services for the culture and differentiation of human embryonic stem cells (ESCs) and human induced pluripotent stem cells (iPSCs) to the CHOP and University of Pennsylvania academic communities. The facility maintains five of the new NIH-approved human ESC lines and several human iPSC lines.

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Clinical Vector Core

The Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia has established a state-of-the-art cGMP clinical vector manufacturing suite for both Adeno Associated Viral Vectors and Lenti Viral Vectors. The facility is under the direction of J. Fraser Wright, Ph.D., a leading expert in clinical vector production and characterization. Our goal is to help to realize the enormous promise of gene transfer therapy to address unmet medical needs.

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Research Vector Core

Part of The Center for Cellular and Molecular Therapeutics, the Research Vector Core is designed and developed to support investigators interested in using viral vectors in their research model systems.

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